Drug interactions
Dexmethylphenidate + Isocarboxazid
Severity: Contraindicated
Dexmethylphenidate and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmethylphenidate with an MAOI can precipitate hypertensive crisis. Labeling prohibits use during or within 14 days of MAOI therapy.
What this interaction means in plain words
Dexmethylphenidate and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibition combined with stimulant-induced catecholamine release and reuptake blockade produces excessive adrenergic stimulation.
What to do
Avoid the combination and allow 14 days after stopping the MAOI before dexmethylphenidate. Consider a non-stimulant ADHD agent only after appropriate washout.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
- Dexmethylphenidate + Selegiline Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dexmethylphenidate with an MAOI can precipitate hypertensive crisis. Labeling prohibits use during or within 14 days of MAOI therapy.
How serious is the interaction between Dexmethylphenidate and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow 14 days after stopping the MAOI before dexmethylphenidate. Consider a non-stimulant ADHD agent only after appropriate washout.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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