Drug interactions
Dexmethylphenidate + Linezolid
Severity: Contraindicated
Dexmethylphenidate and Linezolid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmethylphenidate increases synaptic norepinephrine and dopamine, and linezolid blocks their breakdown. This can provoke hypertensive crisis.
What this interaction means in plain words
Dexmethylphenidate and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
MAO inhibition by linezolid potentiates catecholamines released or retained by dexmethylphenidate.
What to do
Avoid combination and do not give dexmethylphenidate during or within 14 days of an MAOI. If linezolid is essential, hold the stimulant and monitor blood pressure.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
- Dexmethylphenidate + Selegiline Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Linezolid?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dexmethylphenidate increases synaptic norepinephrine and dopamine, and linezolid blocks their breakdown. This can provoke hypertensive crisis.
How serious is the interaction between Dexmethylphenidate and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination and do not give dexmethylphenidate during or within 14 days of an MAOI. If linezolid is essential, hold the stimulant and monitor blood pressure.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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