Drug interactions
Dextroamphetamine + Solriamfetol
Severity: Moderate
Dextroamphetamine and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are wakefulness-promoting agents that increase noradrenergic and dopaminergic activity. Together they can add to increases in blood pressure and heart rate, and cause insomnia, anxiety and agitation.
What this interaction means in plain words
Dextroamphetamine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive sympathomimetic effects through catecholamine reuptake inhibition (solriamfetol) and release (dextroamphetamine).
What to do
Monitor blood pressure and heart rate at baseline and during dose changes. Avoid the combination in patients with uncontrolled hypertension or significant cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Solriamfetol?
MediHelp rates the interaction as moderate. Dextroamphetamine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are wakefulness-promoting agents that increase noradrenergic and dopaminergic activity. Together they can add to increases in blood pressure and heart rate, and cause insomnia, anxiety and agitation.
How serious is the interaction between Dextroamphetamine and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate at baseline and during dose changes. Avoid the combination in patients with uncontrolled hypertension or significant cardiovascular disease.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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