Drug interactions
Linezolid + Solriamfetol
Severity: Contraindicated
Linezolid and Solriamfetol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol raises synaptic dopamine and norepinephrine, and MAO inhibitors such as linezolid prevent their breakdown. This may cause marked increases in blood pressure and heart rate.
What this interaction means in plain words
Linezolid and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Linezolid belongs to Anti Bacterial; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive adrenergic effects from solriamfetol reuptake inhibition and MAO inhibition by linezolid.
What to do
Do not use solriamfetol during or within 14 days of stopping an MAOI including linezolid. Choose an alternative antibiotic or defer solriamfetol.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
- Selegiline + Solriamfetol Contraindicated
Frequently asked questions
Can I take Linezolid with Solriamfetol?
MediHelp rates the interaction as contraindicated. Linezolid and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Solriamfetol raises synaptic dopamine and norepinephrine, and MAO inhibitors such as linezolid prevent their breakdown. This may cause marked increases in blood pressure and heart rate.
How serious is the interaction between Linezolid and Solriamfetol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use solriamfetol during or within 14 days of stopping an MAOI including linezolid. Choose an alternative antibiotic or defer solriamfetol.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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