Drug interactions
Procarbazine + Solriamfetol
Severity: Contraindicated
Procarbazine and Solriamfetol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol with an MAO inhibitor such as procarbazine may cause marked increases in blood pressure and heart rate. The solriamfetol label prohibits use during or within 14 days of MAOI therapy.
What this interaction means in plain words
Procarbazine and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Solriamfetol belongs to Central Nervous System.
Why it happens
MAO inhibition raises catecholamine levels while solriamfetol blocks dopamine and norepinephrine reuptake, producing additive pressor effects.
What to do
Do not use together; separate by at least 14 days after stopping the MAOI. Choose an alternative wake-promoting agent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
- Selegiline + Solriamfetol Contraindicated
Frequently asked questions
Can I take Procarbazine with Solriamfetol?
MediHelp rates the interaction as contraindicated. Procarbazine and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Solriamfetol with an MAO inhibitor such as procarbazine may cause marked increases in blood pressure and heart rate. The solriamfetol label prohibits use during or within 14 days of MAOI therapy.
How serious is the interaction between Procarbazine and Solriamfetol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; separate by at least 14 days after stopping the MAOI. Choose an alternative wake-promoting agent.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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