Drug interactions
Rasagiline + Solriamfetol
Severity: Contraindicated
Rasagiline and Solriamfetol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol is contraindicated with MAO inhibitors and within 14 days of stopping them because of hypertensive reaction risk. Blood pressure and heart rate can rise sharply.
What this interaction means in plain words
Rasagiline and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rasagiline belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Solriamfetol inhibits dopamine and norepinephrine reuptake, while MAO inhibition reduces the degradation of these monoamines, giving additive effects.
What to do
Avoid concurrent use and maintain a 14-day interval after stopping the MAO inhibitor. Choose another wakefulness agent if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
- Selegiline + Solriamfetol Contraindicated
Frequently asked questions
Can I take Rasagiline with Solriamfetol?
MediHelp rates the interaction as contraindicated. Rasagiline and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Solriamfetol is contraindicated with MAO inhibitors and within 14 days of stopping them because of hypertensive reaction risk. Blood pressure and heart rate can rise sharply.
How serious is the interaction between Rasagiline and Solriamfetol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and maintain a 14-day interval after stopping the MAO inhibitor. Choose another wakefulness agent if needed.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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