Drug interactions
Safinamide + Solriamfetol
Severity: Contraindicated
Safinamide and Solriamfetol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol increases dopamine and norepinephrine activity, and MAO inhibitors impair breakdown of these amines. This can cause severe hypertension and hypertensive crisis, and solriamfetol labeling contraindicates use with MAO inhibitors.
What this interaction means in plain words
Safinamide and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Safinamide belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Dopamine and norepinephrine reuptake inhibition by solriamfetol adds to reduced monoamine degradation from MAO inhibition.
What to do
Avoid concurrent use and do not start solriamfetol within 14 days of stopping an MAO inhibitor. Monitor blood pressure if exposure occurs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Selegiline + Solriamfetol Contraindicated
Frequently asked questions
Can I take Safinamide with Solriamfetol?
MediHelp rates the interaction as contraindicated. Safinamide and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Solriamfetol increases dopamine and norepinephrine activity, and MAO inhibitors impair breakdown of these amines. This can cause severe hypertension and hypertensive crisis, and solriamfetol labeling contraindicates use with MAO inhibitors.
How serious is the interaction between Safinamide and Solriamfetol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and do not start solriamfetol within 14 days of stopping an MAO inhibitor. Monitor blood pressure if exposure occurs.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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