Drug interactions
Phenelzine + Solriamfetol
Severity: Contraindicated
Phenelzine and Solriamfetol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol inhibits dopamine and norepinephrine reuptake, and MAO inhibition prevents their breakdown. This risks hypertensive reactions and marked rises in heart rate. Labeling contraindicates use with an MAOI or within 14 days of stopping one.
What this interaction means in plain words
Phenelzine and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Reuptake inhibition of dopamine and norepinephrine is potentiated by irreversible MAO inhibition.
What to do
Do not use during or within 14 days of discontinuing phenelzine. Choose a different wake-promoting agent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
- Selegiline + Solriamfetol Contraindicated
Frequently asked questions
Can I take Phenelzine with Solriamfetol?
MediHelp rates the interaction as contraindicated. Phenelzine and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Solriamfetol inhibits dopamine and norepinephrine reuptake, and MAO inhibition prevents their breakdown. This risks hypertensive reactions and marked rises in heart rate. Labeling contraindicates use with an MAOI or within 14 days of stopping one.
How serious is the interaction between Phenelzine and Solriamfetol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during or within 14 days of discontinuing phenelzine. Choose a different wake-promoting agent.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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