Drug interactions
Isocarboxazid + Solriamfetol
Severity: Contraindicated
Isocarboxazid and Solriamfetol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol raises dopamine and noradrenaline activity, and with an MAOI it can lead to hypertensive crisis. Labeling prohibits use during MAOI therapy and for 14 days after stopping it.
What this interaction means in plain words
Isocarboxazid and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Dopamine and noradrenaline reuptake inhibition augmented by loss of MAO-mediated degradation.
What to do
Avoid during and for 14 days after MAOI use; consider another wake-promoting agent without adrenergic load.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Solriamfetol
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
- Selegiline + Solriamfetol Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Solriamfetol?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Solriamfetol raises dopamine and noradrenaline activity, and with an MAOI it can lead to hypertensive crisis. Labeling prohibits use during MAOI therapy and for 14 days after stopping it.
How serious is the interaction between Isocarboxazid and Solriamfetol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during and for 14 days after MAOI use; consider another wake-promoting agent without adrenergic load.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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