Drug interactions
Dextroamphetamine transdermal + Rolapitant
Severity: Moderate
Dextroamphetamine transdermal and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is partly metabolized by CYP2D6, and rolapitant's prolonged inhibition may raise its levels. Increased exposure can heighten sympathomimetic effects and the risk of serotonin syndrome.
What this interaction means in plain words
Dextroamphetamine transdermal and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6 by rolapitant reduces dextroamphetamine metabolism.
What to do
Use a lower starting dose and monitor for hypertension, tachycardia, agitation and serotonin syndrome. Stop the amphetamine if serotonin toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Dextroamphetamine transdermal with Rolapitant?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine is partly metabolized by CYP2D6, and rolapitant's prolonged inhibition may raise its levels. Increased exposure can heighten sympathomimetic effects and the risk of serotonin syndrome.
How serious is the interaction between Dextroamphetamine transdermal and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower starting dose and monitor for hypertension, tachycardia, agitation and serotonin syndrome. Stop the amphetamine if serotonin toxicity occurs.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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