Drug interactions
Dextromethorphan + Gepirone
Severity: Moderate
Dextromethorphan and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a 5-HT1A agonist antidepressant, and dextromethorphan has serotonergic activity, so serotonin toxicity is possible when combined. Gepirone is also a CYP3A4 substrate, though dextromethorphan is not a major interacting enzyme for it.
What this interaction means in plain words
Dextromethorphan and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextromethorphan belongs to Respiratory; Gepirone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects at 5-HT receptors and serotonin reuptake inhibition.
What to do
Monitor for signs of serotonin syndrome, especially after starting or raising doses. Discontinue one or both agents if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Gepirone?
MediHelp rates the interaction as moderate. Dextromethorphan and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone is a 5-HT1A agonist antidepressant, and dextromethorphan has serotonergic activity, so serotonin toxicity is possible when combined. Gepirone is also a CYP3A4 substrate, though dextromethorphan is not a major interacting enzyme for it.
How serious is the interaction between Dextromethorphan and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome, especially after starting or raising doses. Discontinue one or both agents if symptoms develop.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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