Drug interactions
Dextromethorphan + Ranolazine
Severity: Minor
Dextromethorphan and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine weakly inhibits CYP2D6 and may slightly raise dextromethorphan levels. Clinically meaningful effects are unlikely at usual doses.
What this interaction means in plain words
Dextromethorphan and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextromethorphan belongs to Respiratory; Ranolazine belongs to Cardiovascular.
Why it happens
Weak CYP2D6 inhibition by ranolazine reduces dextromethorphan metabolism.
What to do
No action is generally required; watch for dizziness or sedation if dextromethorphan is used often.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Ranolazine?
MediHelp rates the interaction as minor. Dextromethorphan and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine weakly inhibits CYP2D6 and may slightly raise dextromethorphan levels. Clinically meaningful effects are unlikely at usual doses.
How serious is the interaction between Dextromethorphan and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required; watch for dizziness or sedation if dextromethorphan is used often.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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