Drug interactions
Dextromethorphan + Risperidone
Severity: Minor
Dextromethorphan and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone is a CYP2D6 substrate, and dextromethorphan may compete for this pathway. Dextromethorphan's serotonergic activity also creates a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome with antipsychotics.
What this interaction means in plain words
Dextromethorphan and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextromethorphan belongs to Respiratory; Risperidone belongs to Central Nervous System.
Why it happens
Possible competition at CYP2D6 plus theoretical additive serotonergic and dopaminergic effects.
What to do
No routine dose change is needed; counsel the patient to report fever, rigidity, tremor or confusion promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Dextromethorphan with Risperidone?
MediHelp rates the interaction as minor. Dextromethorphan and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Risperidone is a CYP2D6 substrate, and dextromethorphan may compete for this pathway. Dextromethorphan's serotonergic activity also creates a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome with antipsychotics.
How serious is the interaction between Dextromethorphan and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; counsel the patient to report fever, rigidity, tremor or confusion promptly.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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