Drug interactions
Dextromethorphan + Trimipramine
Severity: Moderate
Dextromethorphan and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine has weak serotonergic activity, but combined use with dextromethorphan may still add to serotonin syndrome risk. Both are CYP2D6 substrates and may compete for metabolism.
What this interaction means in plain words
Dextromethorphan and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextromethorphan belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects and competition for CYP2D6 metabolism.
What to do
Use standard short-course doses of dextromethorphan and monitor for serotonin toxicity and sedation. Use an alternative antitussive if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Trimipramine?
MediHelp rates the interaction as moderate. Dextromethorphan and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine has weak serotonergic activity, but combined use with dextromethorphan may still add to serotonin syndrome risk. Both are CYP2D6 substrates and may compete for metabolism.
How serious is the interaction between Dextromethorphan and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard short-course doses of dextromethorphan and monitor for serotonin toxicity and sedation. Use an alternative antitussive if symptoms occur.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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