Drug interactions
DHEA + Tolvaptan
Severity: Minor
DHEA and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA is not a recognised significant CYP3A4 inhibitor, so any increase in tolvaptan exposure is theoretical. Higher tolvaptan levels could cause excessively rapid sodium correction.
What this interaction means in plain words
DHEA and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
DHEA belongs to Gastrointestinal Tract; Tolvaptan belongs to Endocrine.
Why it happens
Hypothesised CYP3A4 modulation by DHEA; not established.
What to do
Monitor serum sodium as usual during tolvaptan therapy. No dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Ergotamine Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take DHEA with Tolvaptan?
MediHelp rates the interaction as minor. DHEA and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA is not a recognised significant CYP3A4 inhibitor, so any increase in tolvaptan exposure is theoretical. Higher tolvaptan levels could cause excessively rapid sodium correction.
How serious is the interaction between DHEA and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium as usual during tolvaptan therapy. No dose change is required.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Ergotamine. The full list is on the DHEA page.
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