Drug interactions
Diazepam + Elagolix
Severity: Minor
Diazepam and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix weakly inhibits CYP2C19 and induces CYP3A4, so diazepam exposure could change in either direction. The net effect is generally small and unpredictable.
What this interaction means in plain words
Diazepam and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Elagolix belongs to Musculoskeletal.
Why it happens
Opposing effects of CYP2C19 inhibition and CYP3A4 induction by elagolix on diazepam metabolism.
What to do
Monitor clinical response and sedation when elagolix is started or stopped. Adjust the diazepam dose only if effects change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Diazepam with Elagolix?
MediHelp rates the interaction as minor. Diazepam and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix weakly inhibits CYP2C19 and induces CYP3A4, so diazepam exposure could change in either direction. The net effect is generally small and unpredictable.
How serious is the interaction between Diazepam and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and sedation when elagolix is started or stopped. Adjust the diazepam dose only if effects change.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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