Drug interactions
Diazepam + Enzalutamide
Severity: Moderate
Diazepam and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can reduce diazepam exposure, potentially weakening its anxiolytic or anticonvulsant effect. The effect develops over weeks and persists after enzalutamide is stopped.
What this interaction means in plain words
Diazepam and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4 (and CYP2C19), increasing diazepam metabolism.
What to do
Monitor for reduced diazepam effect and adjust the dose accordingly; reassess dose when enzalutamide is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Diazepam with Enzalutamide?
MediHelp rates the interaction as moderate. Diazepam and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can reduce diazepam exposure, potentially weakening its anxiolytic or anticonvulsant effect. The effect develops over weeks and persists after enzalutamide is stopped.
How serious is the interaction between Diazepam and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced diazepam effect and adjust the dose accordingly; reassess dose when enzalutamide is discontinued.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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