Drug interactions
Diazepam + Metoclopramide
Severity: Moderate
Diazepam and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying and has been shown to increase the rate of diazepam absorption, which can lead to quicker onset and greater sedation. Both drugs also cause drowsiness independently.
What this interaction means in plain words
Diazepam and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression and faster diazepam absorption due to accelerated gastric emptying.
What to do
Monitor for oversedation and psychomotor impairment, and advise against driving. Reduce the diazepam dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Metoclopramide?
MediHelp rates the interaction as moderate. Diazepam and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide speeds gastric emptying and has been shown to increase the rate of diazepam absorption, which can lead to quicker onset and greater sedation. Both drugs also cause drowsiness independently.
How serious is the interaction between Diazepam and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and psychomotor impairment, and advise against driving. Reduce the diazepam dose if excessive sedation occurs.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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