Drug interactions
Diazepam + Perampanel
Severity: Moderate
Diazepam and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel can cause somnolence, dizziness and impaired coordination, and these effects add to those of diazepam. Perampanel may also cause mood or behavioral changes, which sedatives can complicate.
What this interaction means in plain words
Diazepam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression; perampanel is an AMPA receptor antagonist and diazepam potentiates GABA-A.
What to do
Monitor for excessive sedation and psychomotor impairment, particularly during perampanel titration. Counsel patients regarding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Diazepam with Perampanel?
MediHelp rates the interaction as moderate. Diazepam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel can cause somnolence, dizziness and impaired coordination, and these effects add to those of diazepam. Perampanel may also cause mood or behavioral changes, which sedatives can complicate.
How serious is the interaction between Diazepam and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and psychomotor impairment, particularly during perampanel titration. Counsel patients regarding driving and alcohol.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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