Drug interactions
Diazepam + Posaconazole
Severity: Moderate
Diazepam and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits the CYP3A4 pathway that contributes to diazepam clearance, which can raise diazepam exposure and prolong its effects. Excessive sedation, psychomotor impairment and respiratory depression may result, particularly in older or frail patients.
What this interaction means in plain words
Diazepam and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole is a strong CYP3A4 inhibitor that reduces the oxidative metabolism of diazepam.
What to do
Monitor for oversedation and consider a lower diazepam dose during posaconazole therapy. Reduce the dose again or choose a benzodiazepine cleared by glucuronidation such as lorazepam if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Diazepam with Posaconazole?
MediHelp rates the interaction as moderate. Diazepam and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole inhibits the CYP3A4 pathway that contributes to diazepam clearance, which can raise diazepam exposure and prolong its effects. Excessive sedation, psychomotor impairment and respiratory depression may result, particularly in older or frail patients.
How serious is the interaction between Diazepam and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider a lower diazepam dose during posaconazole therapy. Reduce the dose again or choose a benzodiazepine cleared by glucuronidation such as lorazepam if sedation is excessive.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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