Drug interactions
Diazepam + Prochlorperazine
Severity: Moderate
Diazepam and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases sedation, psychomotor impairment and dizziness. Falls and excess CNS depression are more likely in older or frail patients and with higher doses.
What this interaction means in plain words
Diazepam and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from dopamine, histamine and alpha-adrenergic blockade combined with GABA-A potentiation.
What to do
Use the lowest effective doses and warn patients about driving and operating machinery. Monitor sedation and respiratory status, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diazepam and Prochlorperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Prochlorperazine?
MediHelp rates the interaction as moderate. Diazepam and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use increases sedation, psychomotor impairment and dizziness. Falls and excess CNS depression are more likely in older or frail patients and with higher doses.
How serious is the interaction between Diazepam and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn patients about driving and operating machinery. Monitor sedation and respiratory status, especially in older adults.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
