Drug interactions
Diazepam + Propofol
Severity: Moderate
Diazepam and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining propofol with diazepam produces additive central nervous system and respiratory depression. Hypotension and apnea are more likely, and the propofol dose required for induction or sedation is generally reduced.
What this interaction means in plain words
Diazepam and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Propofol belongs to Central Nervous System.
Why it happens
Both drugs enhance GABA-A receptor mediated inhibition, producing additive CNS depression.
What to do
Titrate propofol to effect and reduce its dose when diazepam has been given. Use continuous monitoring of oxygen saturation, respiration and blood pressure by staff skilled in airway management.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Propofol
Frequently asked questions
Can I take Diazepam with Propofol?
MediHelp rates the interaction as moderate. Diazepam and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining propofol with diazepam produces additive central nervous system and respiratory depression. Hypotension and apnea are more likely, and the propofol dose required for induction or sedation is generally reduced.
How serious is the interaction between Diazepam and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and reduce its dose when diazepam has been given. Use continuous monitoring of oxygen saturation, respiration and blood pressure by staff skilled in airway management.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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