Drug interactions
Diazepam + Tucatinib
Severity: Moderate
Diazepam and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and can raise exposure to CYP3A substrates such as diazepam. This may increase sedation and psychomotor impairment.
What this interaction means in plain words
Diazepam and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing diazepam clearance.
What to do
Monitor for oversedation and consider reducing the diazepam dose. Consider lorazepam if a benzodiazepine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Diazepam with Tucatinib?
MediHelp rates the interaction as moderate. Diazepam and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a moderate CYP3A inhibitor and can raise exposure to CYP3A substrates such as diazepam. This may increase sedation and psychomotor impairment.
How serious is the interaction between Diazepam and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider reducing the diazepam dose. Consider lorazepam if a benzodiazepine is needed.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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