Drug interactions
Diazoxide + Hydrochlorothiazide-irbesartan
Severity: Moderate
Diazoxide and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and diazoxide raise blood glucose, and together they can cause marked hyperglycemia and may also enhance hypotension. Hyperuricemia and electrolyte disturbance can also be additive.
What this interaction means in plain words
Diazoxide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive hyperglycemic effects: diazoxide suppresses insulin secretion via K-ATP channel opening and thiazides impair glucose tolerance.
What to do
Monitor blood glucose, blood pressure and electrolytes, and adjust diazoxide or antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Diazoxide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and diazoxide raise blood glucose, and together they can cause marked hyperglycemia and may also enhance hypotension. Hyperuricemia and electrolyte disturbance can also be additive.
How serious is the interaction between Diazoxide and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure and electrolytes, and adjust diazoxide or antidiabetic therapy as needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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