Drug interactions
Diazoxide + Metolazone
Severity: Moderate
Diazoxide and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both diazoxide and thiazide-type diuretics can raise blood glucose, and diazoxide may also cause sodium and fluid retention that metolazone partly offsets. Together they can worsen hyperglycemia and add to hypotension, hypokalemia and hyperuricemia.
What this interaction means in plain words
Diazoxide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Metolazone belongs to Cardiovascular.
Why it happens
Additive hyperglycemic effects from inhibition of insulin release (diazoxide) and impaired glucose tolerance (thiazides).
What to do
Monitor blood glucose, potassium and blood pressure, and adjust antidiabetic therapy if glucose rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Metolazone?
MediHelp rates the interaction as moderate. Diazoxide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both diazoxide and thiazide-type diuretics can raise blood glucose, and diazoxide may also cause sodium and fluid retention that metolazone partly offsets. Together they can worsen hyperglycemia and add to hypotension, hypokalemia and hyperuricemia.
How serious is the interaction between Diazoxide and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and blood pressure, and adjust antidiabetic therapy if glucose rises.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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