Drug interactions
Diclofenac + Digoxin
Severity: Moderate
Diclofenac and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and glomerular filtration, which may reduce digoxin clearance and raise serum digoxin concentrations. This can result in digoxin toxicity, particularly in elderly patients or those with renal impairment.
What this interaction means in plain words
Diclofenac and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Digoxin belongs to Cardiovascular.
Why it happens
NSAID-mediated inhibition of renal prostaglandins reduces renal perfusion and digoxin elimination.
What to do
Monitor serum digoxin levels and renal function when starting or stopping diclofenac. Reduce the digoxin dose if concentrations rise or toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Diclofenac with Digoxin?
MediHelp rates the interaction as moderate. Diclofenac and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and glomerular filtration, which may reduce digoxin clearance and raise serum digoxin concentrations. This can result in digoxin toxicity, particularly in elderly patients or those with renal impairment.
How serious is the interaction between Diclofenac and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and renal function when starting or stopping diclofenac. Reduce the digoxin dose if concentrations rise or toxicity appears.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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