Drug interactions
Diclofenac + Finerenone
Severity: Moderate
Diclofenac and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac is not a recognized clinically important CYP3A4 inhibitor, but NSAIDs and finerenone both affect renal function and potassium. Together they may raise the risk of hyperkalemia and acute kidney injury.
What this interaction means in plain words
Diclofenac and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Finerenone belongs to Cardiovascular.
Why it happens
Additive hyperkalemia and renal hemodynamic effects from NSAID prostaglandin inhibition and mineralocorticoid receptor blockade.
What to do
Monitor serum potassium and eGFR after starting the combination and periodically afterward. Withhold finerenone if potassium rises above recommended limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diclofenac and Finerenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Diclofenac with Finerenone?
MediHelp rates the interaction as moderate. Diclofenac and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac is not a recognized clinically important CYP3A4 inhibitor, but NSAIDs and finerenone both affect renal function and potassium. Together they may raise the risk of hyperkalemia and acute kidney injury.
How serious is the interaction between Diclofenac and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR after starting the combination and periodically afterward. Withhold finerenone if potassium rises above recommended limits.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
