Drug interactions
Diclofenac + Fluconazole
Severity: Moderate
Diclofenac and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C9, the main enzyme in diclofenac 4'-hydroxylation, which raises diclofenac exposure. This increases the risk of gastrointestinal, renal and cardiovascular adverse effects.
What this interaction means in plain words
Diclofenac and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C9-mediated diclofenac metabolism by fluconazole.
What to do
Consider reducing the diclofenac dose and monitor for NSAID toxicity during co-therapy. Review need for the NSAID if fluconazole is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Diclofenac with Fluconazole?
MediHelp rates the interaction as moderate. Diclofenac and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C9, the main enzyme in diclofenac 4'-hydroxylation, which raises diclofenac exposure. This increases the risk of gastrointestinal, renal and cardiovascular adverse effects.
How serious is the interaction between Diclofenac and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the diclofenac dose and monitor for NSAID toxicity during co-therapy. Review need for the NSAID if fluconazole is prolonged.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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