Drug interactions
Diclofenac + Glipizide
Severity: Moderate
Diclofenac and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect with diclofenac is usually modest but is more relevant in elderly or renally impaired patients.
What this interaction means in plain words
Diclofenac and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Glipizide belongs to Endocrine.
Why it happens
Possible competition for CYP2C9 metabolism and protein-binding displacement; mechanism not fully established.
What to do
Monitor blood glucose when starting or stopping diclofenac and adjust the glipizide dose if needed. Teach patients to recognize hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Glipizide
Frequently asked questions
Can I take Diclofenac with Glipizide?
MediHelp rates the interaction as moderate. Diclofenac and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect with diclofenac is usually modest but is more relevant in elderly or renally impaired patients.
How serious is the interaction between Diclofenac and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping diclofenac and adjust the glipizide dose if needed. Teach patients to recognize hypoglycemia symptoms.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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