Drug interactions
Diclofenac + Levoketoconazole
Severity: Moderate
Diclofenac and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole may inhibit CYP2C9 and raise diclofenac exposure, increasing the risk of NSAID adverse effects such as gastrointestinal bleeding and renal impairment. Levoketoconazole also has other significant interaction and QT concerns, but the effect on diclofenac is the relevant point here.
What this interaction means in plain words
Diclofenac and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP2C9-mediated diclofenac metabolism, increasing diclofenac plasma levels.
What to do
Limit the diclofenac dose to the lowest effective amount, not exceeding 50 mg twice daily. Monitor for gastrointestinal, renal and cardiovascular adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Diclofenac with Levoketoconazole?
MediHelp rates the interaction as moderate. Diclofenac and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole may inhibit CYP2C9 and raise diclofenac exposure, increasing the risk of NSAID adverse effects such as gastrointestinal bleeding and renal impairment. Levoketoconazole also has other significant interaction and QT concerns, but the effect on diclofenac is the relevant point here.
How serious is the interaction between Diclofenac and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the diclofenac dose to the lowest effective amount, not exceeding 50 mg twice daily. Monitor for gastrointestinal, renal and cardiovascular adverse effects.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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