Drug interactions
Diclofenac + Rucaparib
Severity: Moderate
Diclofenac and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9 in vitro and in clinical data, which can raise exposure to CYP2C9 substrates such as diclofenac. Higher diclofenac levels could increase the risk of gastrointestinal, renal and cardiovascular adverse effects.
What this interaction means in plain words
Diclofenac and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C9, reducing the oxidative metabolism of diclofenac.
What to do
Use the lowest effective diclofenac dose for the shortest duration and monitor for GI bleeding, edema and renal function. Consider a lower diclofenac dose or an alternative analgesic if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Diclofenac with Rucaparib?
MediHelp rates the interaction as moderate. Diclofenac and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP2C9 in vitro and in clinical data, which can raise exposure to CYP2C9 substrates such as diclofenac. Higher diclofenac levels could increase the risk of gastrointestinal, renal and cardiovascular adverse effects.
How serious is the interaction between Diclofenac and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose for the shortest duration and monitor for GI bleeding, edema and renal function. Consider a lower diclofenac dose or an alternative analgesic if adverse effects appear.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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