Drug interactions
Diclofenac + Vortioxetine
Severity: Moderate
Diclofenac and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine affects serotonin reuptake in platelets and, with diclofenac, increases the risk of bleeding including gastrointestinal hemorrhage.
What this interaction means in plain words
Diclofenac and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive effects on platelet function from serotonergic reuptake inhibition and COX inhibition.
What to do
Monitor for bruising, GI bleeding or anemia, and consider gastroprotection in high-risk patients. Keep NSAID exposure as short as possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Diclofenac with Vortioxetine?
MediHelp rates the interaction as moderate. Diclofenac and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine affects serotonin reuptake in platelets and, with diclofenac, increases the risk of bleeding including gastrointestinal hemorrhage.
How serious is the interaction between Diclofenac and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, GI bleeding or anemia, and consider gastroprotection in high-risk patients. Keep NSAID exposure as short as possible.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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