Drug interactions
Dicloxacillin + Ethinyl estradiol-drospirenone
Severity: Minor
Dicloxacillin and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-rifamycin antibiotics such as dicloxacillin have been theorized to lower contraceptive hormone exposure. Pharmacokinetic studies and epidemiology have not shown a consistent loss of contraceptive efficacy.
What this interaction means in plain words
Dicloxacillin and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dicloxacillin belongs to Anti Bacterial; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Theoretical reduction of enterohepatic recycling of ethinyl estradiol through altered gut flora, not confirmed in pharmacokinetic studies.
What to do
No routine change is needed; counsel the patient to take pills consistently and to use backup contraception if vomiting or severe diarrhea occurs during the illness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Dicloxacillin and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-rifamycin antibiotics such as dicloxacillin have been theorized to lower contraceptive hormone exposure. Pharmacokinetic studies and epidemiology have not shown a consistent loss of contraceptive efficacy.
How serious is the interaction between Dicloxacillin and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient to take pills consistently and to use backup contraception if vomiting or severe diarrhea occurs during the illness.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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