Drug interactions
Dicloxacillin + Piroxicam
Severity: Minor
Dicloxacillin and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins compete with NSAIDs for renal tubular secretion, which may modestly raise levels of either drug, and both are highly protein bound. Clinical significance is generally small with dicloxacillin and piroxicam.
What this interaction means in plain words
Dicloxacillin and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dicloxacillin belongs to Anti Bacterial; Piroxicam belongs to Musculoskeletal.
Why it happens
Possible competition for renal tubular organic anion secretion and protein binding sites.
What to do
No routine adjustment is needed; watch for increased NSAID adverse effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Piroxicam?
MediHelp rates the interaction as minor. Dicloxacillin and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins compete with NSAIDs for renal tubular secretion, which may modestly raise levels of either drug, and both are highly protein bound. Clinical significance is generally small with dicloxacillin and piroxicam.
How serious is the interaction between Dicloxacillin and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for increased NSAID adverse effects during prolonged co-therapy.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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