Drug interactions
Dicloxacillin + Tazemetostat
Severity: Moderate
Dicloxacillin and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicloxacillin is a weak to moderate CYP3A4 inducer and may lower tazemetostat exposure, which is a CYP3A4 substrate. Reduced exposure could diminish antitumor efficacy.
What this interaction means in plain words
Dicloxacillin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicloxacillin belongs to Anti Bacterial; Tazemetostat belongs to Miscellaneous.
Why it happens
CYP3A4 induction by dicloxacillin increases tazemetostat metabolism.
What to do
Monitor for reduced tumor response and prefer a non-inducing antibacterial when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Other interactions of Tazemetostat
Frequently asked questions
Can I take Dicloxacillin with Tazemetostat?
MediHelp rates the interaction as moderate. Dicloxacillin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicloxacillin is a weak to moderate CYP3A4 inducer and may lower tazemetostat exposure, which is a CYP3A4 substrate. Reduced exposure could diminish antitumor efficacy.
How serious is the interaction between Dicloxacillin and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tumor response and prefer a non-inducing antibacterial when feasible.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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