Drug interactions
Dicyclomine + Fluphenazine
Severity: Moderate
Dicyclomine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has anticholinergic properties in addition to dopamine blockade, so combined use increases anticholinergic burden with constipation, urinary retention, dry mouth and confusion. Anticholinergics may also slow gastric emptying and modestly alter antipsychotic absorption.
What this interaction means in plain words
Dicyclomine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects; anticholinergic slowing of GI motility may alter oral antipsychotic absorption.
What to do
Monitor for anticholinergic toxicity, bowel obstruction signs and loss of antipsychotic control. Consider an alternative to dicyclomine in patients with dementia or older age.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Dicyclomine with Fluphenazine?
MediHelp rates the interaction as moderate. Dicyclomine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has anticholinergic properties in addition to dopamine blockade, so combined use increases anticholinergic burden with constipation, urinary retention, dry mouth and confusion. Anticholinergics may also slow gastric emptying and modestly alter antipsychotic absorption.
How serious is the interaction between Dicyclomine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, bowel obstruction signs and loss of antipsychotic control. Consider an alternative to dicyclomine in patients with dementia or older age.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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