Drug interactions
Dicyclomine + Haloperidol
Severity: Moderate
Dicyclomine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining these drugs may increase anticholinergic effects such as constipation, urinary retention, dry mouth and confusion, although haloperidol itself has weak anticholinergic activity. Anticholinergics can also slow gastric transit and may modestly change antipsychotic absorption.
What this interaction means in plain words
Dicyclomine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Haloperidol belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects and anticholinergic reduction of GI motility affecting oral absorption.
What to do
Monitor for anticholinergic adverse effects and for changes in psychiatric symptom control. Use the lowest effective dicyclomine dose, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Dicyclomine with Haloperidol?
MediHelp rates the interaction as moderate. Dicyclomine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining these drugs may increase anticholinergic effects such as constipation, urinary retention, dry mouth and confusion, although haloperidol itself has weak anticholinergic activity. Anticholinergics can also slow gastric transit and may modestly change antipsychotic absorption.
How serious is the interaction between Dicyclomine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and for changes in psychiatric symptom control. Use the lowest effective dicyclomine dose, especially in older patients.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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