Drug interactions
Dicyclomine + Iloperidone
Severity: Moderate
Dicyclomine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has some antimuscarinic activity, so combining it with dicyclomine increases anticholinergic effects such as constipation, urinary retention, blurred vision and tachycardia. Reduced gut motility from dicyclomine may also modestly change oral drug absorption.
What this interaction means in plain words
Dicyclomine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
Additive anticholinergic effects, with possible delayed gastric emptying affecting oral absorption.
What to do
Monitor for constipation, urinary retention and cognitive effects, and assess antipsychotic response; lower the anticholinergic dose if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dicyclomine with Iloperidone?
MediHelp rates the interaction as moderate. Dicyclomine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has some antimuscarinic activity, so combining it with dicyclomine increases anticholinergic effects such as constipation, urinary retention, blurred vision and tachycardia. Reduced gut motility from dicyclomine may also modestly change oral drug absorption.
How serious is the interaction between Dicyclomine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, urinary retention and cognitive effects, and assess antipsychotic response; lower the anticholinergic dose if symptoms develop.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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