Drug interactions
Dicyclomine + Ipratropium
Severity: Moderate
Dicyclomine and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicyclomine is an antispasmodic with anticholinergic action, so combining it with ipratropium may increase dry mouth, constipation, urinary retention, tachycardia and blurred vision. The impact is usually limited by the low systemic absorption of inhaled ipratropium.
What this interaction means in plain words
Dicyclomine and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Ipratropium belongs to Respiratory.
Why it happens
Additive antagonism of muscarinic receptors.
What to do
Monitor for anticholinergic adverse effects, especially in older adults. Reduce the dicyclomine dose if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Ipratropium?
MediHelp rates the interaction as moderate. Dicyclomine and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicyclomine is an antispasmodic with anticholinergic action, so combining it with ipratropium may increase dry mouth, constipation, urinary retention, tachycardia and blurred vision. The impact is usually limited by the low systemic absorption of inhaled ipratropium.
How serious is the interaction between Dicyclomine and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in older adults. Reduce the dicyclomine dose if symptoms develop.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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