Drug interactions
Dicyclomine + Perphenazine
Severity: Moderate
Dicyclomine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has some anticholinergic activity, so combined use adds to constipation, dry mouth, urinary retention and confusion. Slowed gut motility may also modestly alter absorption of oral perphenazine.
What this interaction means in plain words
Dicyclomine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects and possible altered oral absorption.
What to do
Monitor for anticholinergic adverse effects and psychiatric symptom control. Use the lowest effective dicyclomine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Dicyclomine with Perphenazine?
MediHelp rates the interaction as moderate. Dicyclomine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has some anticholinergic activity, so combined use adds to constipation, dry mouth, urinary retention and confusion. Slowed gut motility may also modestly alter absorption of oral perphenazine.
How serious is the interaction between Dicyclomine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and psychiatric symptom control. Use the lowest effective dicyclomine dose.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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