Drug interactions
Dicyclomine + Revefenacin
Severity: Moderate
Dicyclomine and Revefenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Revefenacin is an inhaled long-acting muscarinic antagonist with low systemic exposure. Combined with oral dicyclomine, additive anticholinergic effects may occur, such as dry mouth, urinary retention and constipation.
What this interaction means in plain words
Dicyclomine and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Revefenacin belongs to Respiratory.
Why it happens
Additive antimuscarinic effects at peripheral cholinergic receptors.
What to do
Monitor for urinary retention, constipation, dry mouth and narrow-angle glaucoma symptoms. Reduce or stop dicyclomine if anticholinergic effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Dicyclomine with Revefenacin?
MediHelp rates the interaction as moderate. Dicyclomine and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Revefenacin is an inhaled long-acting muscarinic antagonist with low systemic exposure. Combined with oral dicyclomine, additive anticholinergic effects may occur, such as dry mouth, urinary retention and constipation.
How serious is the interaction between Dicyclomine and Revefenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, dry mouth and narrow-angle glaucoma symptoms. Reduce or stop dicyclomine if anticholinergic effects develop.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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