Drug interactions
Didanosine + Posaconazole
Severity: Minor
Didanosine and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations raise gastric pH, which can reduce absorption of posaconazole oral suspension and potentially lower antifungal exposure. The effect is less relevant for posaconazole delayed-release tablets or modern didanosine formulations.
What this interaction means in plain words
Didanosine and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Didanosine belongs to Anti Virals; Posaconazole belongs to Anti Fungals.
Why it happens
Increased gastric pH decreases dissolution and absorption of posaconazole suspension.
What to do
Separate administration by at least 2 hours, give posaconazole with food, or use the delayed-release tablet; monitor antifungal response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Posaconazole?
MediHelp rates the interaction as minor. Didanosine and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buffered didanosine formulations raise gastric pH, which can reduce absorption of posaconazole oral suspension and potentially lower antifungal exposure. The effect is less relevant for posaconazole delayed-release tablets or modern didanosine formulations.
How serious is the interaction between Didanosine and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 2 hours, give posaconazole with food, or use the delayed-release tablet; monitor antifungal response.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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