Drug interactions
Difelikefalin + Dronabinol
Severity: Moderate
Difelikefalin and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a kappa-opioid agonist, can cause somnolence and dizziness. Combined with dronabinol, sedation and impaired alertness may be greater.
What this interaction means in plain words
Difelikefalin and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Dronabinol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Monitor for excessive drowsiness and dizziness, and advise patients to avoid driving or hazardous tasks until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Dronabinol?
MediHelp rates the interaction as moderate. Difelikefalin and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a kappa-opioid agonist, can cause somnolence and dizziness. Combined with dronabinol, sedation and impaired alertness may be greater.
How serious is the interaction between Difelikefalin and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and dizziness, and advise patients to avoid driving or hazardous tasks until the response is known.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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