Drug interactions
Difelikefalin + Entacapone
Severity: Minor
Difelikefalin and Entacapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause dizziness and somnolence, and entacapone may add to these effects. Falls are a concern in dialysis patients.
What this interaction means in plain words
Difelikefalin and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Difelikefalin belongs to Dermatology; Entacapone belongs to Central Nervous System.
Why it happens
Additive CNS effects.
What to do
Monitor for drowsiness and dizziness and advise caution when standing or driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Entacapone?
MediHelp rates the interaction as minor. Difelikefalin and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin can cause dizziness and somnolence, and entacapone may add to these effects. Falls are a concern in dialysis patients.
How serious is the interaction between Difelikefalin and Entacapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness and advise caution when standing or driving.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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