Drug interactions
Difelikefalin + Lurasidone
Severity: Moderate
Difelikefalin and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness. Used together, they may produce additive sedation and impair alertness and psychomotor performance, which raises the risk of falls, particularly in dialysis patients.
What this interaction means in plain words
Difelikefalin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Lurasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects (pharmacodynamic).
What to do
Monitor for excessive sedation, dizziness and falls, especially after starting or increasing either drug. Advise patients to avoid driving or hazardous tasks until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Lurasidone?
MediHelp rates the interaction as moderate. Difelikefalin and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness. Used together, they may produce additive sedation and impair alertness and psychomotor performance, which raises the risk of falls, particularly in dialysis patients.
How serious is the interaction between Difelikefalin and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and falls, especially after starting or increasing either drug. Advise patients to avoid driving or hazardous tasks until the response is known.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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