Drug interactions
Difelikefalin + Nabilone
Severity: Moderate
Difelikefalin and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a peripherally restricted kappa-opioid agonist, can cause somnolence and dizziness, and nabilone also causes drowsiness. Taken together they may increase sedation and the risk of falls.
What this interaction means in plain words
Difelikefalin and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive drowsiness, dizziness and falls, particularly in dialysis patients and older adults. Reduce the dose or stop one agent if sedation becomes troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Nabilone?
MediHelp rates the interaction as moderate. Difelikefalin and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a peripherally restricted kappa-opioid agonist, can cause somnolence and dizziness, and nabilone also causes drowsiness. Taken together they may increase sedation and the risk of falls.
How serious is the interaction between Difelikefalin and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, dizziness and falls, particularly in dialysis patients and older adults. Reduce the dose or stop one agent if sedation becomes troublesome.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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