Drug interactions
Diflunisal + Duloxetine
Severity: Moderate
Diflunisal and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine inhibits serotonin reuptake and can impair platelet function, which adds to NSAID bleeding risk. The combination increases the chance of GI and other bleeding.
What this interaction means in plain words
Diflunisal and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Duloxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake impairs aggregation, adding to NSAID antiplatelet effect and gastric mucosal injury.
What to do
Avoid if possible or add gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Diflunisal with Duloxetine?
MediHelp rates the interaction as moderate. Diflunisal and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine inhibits serotonin reuptake and can impair platelet function, which adds to NSAID bleeding risk. The combination increases the chance of GI and other bleeding.
How serious is the interaction between Diflunisal and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or add gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for signs of bleeding.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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