Drug interactions
Diflunisal + Glipizide
Severity: Moderate
Diflunisal and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is variable and typically modest.
What this interaction means in plain words
Diflunisal and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Glipizide belongs to Endocrine.
Why it happens
Possible displacement of the sulfonylurea from plasma proteins and NSAID effects on prostaglandins affecting insulin secretion; not well established.
What to do
Monitor blood glucose when starting or stopping diflunisal and teach patients to recognize hypoglycemia. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Glipizide
Frequently asked questions
Can I take Diflunisal with Glipizide?
MediHelp rates the interaction as moderate. Diflunisal and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is variable and typically modest.
How serious is the interaction between Diflunisal and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping diflunisal and teach patients to recognize hypoglycemia. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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