Drug interactions
Diflunisal + Paromomycin
Severity: Minor
Diflunisal and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and raise aminoglycoside levels, as seen in preterm infants. Oral paromomycin is minimally absorbed, so a systemic effect is unlikely in most patients.
What this interaction means in plain words
Diflunisal and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
NSAID-related reduction in renal function may reduce clearance of any absorbed aminoglycoside.
What to do
No action is usually required; monitor renal function in patients with renal impairment or inflamed bowel where absorption may increase.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Diflunisal with Paromomycin?
MediHelp rates the interaction as minor. Diflunisal and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce renal function and raise aminoglycoside levels, as seen in preterm infants. Oral paromomycin is minimally absorbed, so a systemic effect is unlikely in most patients.
How serious is the interaction between Diflunisal and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually required; monitor renal function in patients with renal impairment or inflamed bowel where absorption may increase.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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