Drug interactions
Diflunisal + Sotalol
Severity: Moderate
Diflunisal and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use may reduce the blood pressure lowering effect of sotalol. NSAID-related renal impairment may also raise sotalol levels, since it is renally cleared, increasing proarrhythmic risk.
What this interaction means in plain words
Diflunisal and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Sotalol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes fluid retention, and reduced renal function can lower sotalol elimination.
What to do
Monitor blood pressure, renal function and ECG/QT interval if renal function declines, and adjust the sotalol dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Diflunisal with Sotalol?
MediHelp rates the interaction as moderate. Diflunisal and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use may reduce the blood pressure lowering effect of sotalol. NSAID-related renal impairment may also raise sotalol levels, since it is renally cleared, increasing proarrhythmic risk.
How serious is the interaction between Diflunisal and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and ECG/QT interval if renal function declines, and adjust the sotalol dose accordingly.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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